PDRN Salmon DNA Injection in Korea 2026: Prices, Benefits & Best Clinics

If you have been following the Korean beauty scene, you have probably heard of the so-called "salmon injection" — a PDRN injection in Korea that has become one of the most sought-after skin rejuvenation treatments in Seoul dermatology clinics. Short for Polydeoxyribonucleotide, PDRN is derived from salmon DNA and works at the cellular level to regenerate damaged skin, boost collagen production, and restore a youthful, radiant complexion. Originally developed for wound healing and medical recovery, PDRN has rapidly become a staple of Korean aesthetic medicine, attracting both locals and international visitors looking for cutting-edge skin treatments at a fraction of Western prices.

In this guide, we break down everything you need to know about getting PDRN injections in Seoul in 2026 — from the science behind it and how it compares to Rejuran and exosome treatments, to current pricing, what to expect during the procedure, and the best clinics for international patients.

What Is PDRN? How Does Salmon DNA Work?

PDRN stands for Polydeoxyribonucleotide — essentially, small fragments of DNA extracted from salmon sperm cells (specifically from the testes of salmon and trout). These DNA fragments are biocompatible with human tissue, meaning they carry a very low risk of rejection or allergic reaction.

When injected into the skin, PDRN works through several key mechanisms:

• Cell Regeneration: PDRN activates the A2A adenosine receptor, which stimulates fibroblast proliferation — the cells responsible for producing collagen and elastin in your skin.
• Anti-Inflammatory Action: It promotes the release of anti-inflammatory cytokines and growth factors, reducing redness, irritation, and inflammation at the cellular level.
• Angiogenesis: PDRN encourages the formation of new blood vessels, improving blood supply to damaged tissues and accelerating the healing process.
• Collagen Synthesis: By activating fibroblasts, PDRN boosts the production of collagen and elastin, increasing skin thickness, firmness, and elasticity over time.

Originally used in medical settings for treating diabetic ulcers, burns, and surgical wound recovery, PDRN crossed into aesthetic medicine in the 2010s. Korean dermatologists quickly recognized its potential for improving fine lines, acne scarring, skin texture, redness, and overall skin quality — and the "salmon injection" was born.

PDRN vs Rejuran vs Exosome: What Is the Difference?

One of the most common questions international patients ask is how PDRN compares to Rejuran and exosome treatments. All three are popular skin boosters in Korean clinics, but they differ in composition, delivery method, and results.

Key takeaway: PDRN is the most affordable option and excels at anti-inflammation and tissue repair. Rejuran (PN) is the premium injectable skin booster with stronger collagen-stimulating properties. Exosome treatments are non-invasive but results vary more between individuals — and as of 2025, Korean dermatologists are increasingly favoring injectable skin boosters like Rejuran over exosomes due to more consistent and predictable outcomes.

Many Korean clinics actually recommend combining PDRN with Rejuran: get professional PN injections at the clinic for deep dermal regeneration, then maintain results at home with PDRN-infused skincare products for epidermal repair.

PDRN Injection Prices in Seoul (2026)

One of the biggest advantages of getting PDRN injections in Korea is the price. Compared to Western countries, Korean clinics offer these treatments at a fraction of the cost, with no compromise on quality or safety.

Based on data from Korean medical review platforms as of January 2026:

National average: The average PDRN injection price across Korea is approximately ₩105,000 ($80 USD), though Seoul clinics — especially in Gangnam — tend to charge at the higher end of the range.

Prices as of February 2026. PDRN is classified as a non-covered (non-insurance) procedure in Korea, so prices vary by clinic. Exchange rate: ₩1,300 = $1 USD. Contact clinics directly for current pricing.

How Does This Compare Internationally?

Seoul remains the most affordable destination for PDRN treatments, and Korean clinics have the most extensive experience with these injections given that the treatment originated and was popularized here.

The Procedure: What to Expect

Getting a PDRN injection in Seoul is a straightforward, minimally invasive procedure. Here is what a typical session looks like:

Before Your Appointment

• Consultation: The dermatologist will assess your skin condition, discuss your goals, and recommend a treatment plan. Many clinics offer online consultations in English before you arrive in Korea.
• Allergy Check: If you have a known allergy to seafood (particularly salmon), inform your doctor. While rare, allergic reactions to PDRN can include hives, itching, or localized rash.
• Preparation: Avoid blood thinners, alcohol, and aspirin for 2-3 days before your appointment to minimize bruising.

During the Procedure

1. Cleansing: Your face is thoroughly cleansed and disinfected.
2. Numbing: A topical anesthetic cream is applied and left for 20-30 minutes.
3. Injection: The PDRN solution is injected into the target areas using fine needles or a mesotherapy gun. Common injection sites include the cheeks, forehead, under-eyes, jawline, and neck.
4. Duration: The entire procedure takes approximately 15-30 minutes depending on the treatment area.

Recommended Treatment Schedule

Most Korean dermatologists recommend 3-5 sessions spaced 1-2 weeks apart for optimal results. After the initial course, maintenance sessions every 2-3 months can help sustain the benefits.

Side Effects and Recovery

PDRN injections are considered very safe, with side effects being mild and temporary:

• Common (1-3 days): Minor swelling, redness, small bruises, and slight tenderness at injection sites. A temporary "bumpy" or "embossed" texture on the skin surface is normal and resolves within hours to a couple of days.
• Uncommon: Mild itching or warmth at the injection area.
• Rare: Allergic reaction in individuals sensitive to salmon or seafood-derived products.

Post-Treatment Care

• Cleanse your face with lukewarm or cool water and a gentle, low-irritation cleanser for the first few days.
• Apply moisturizer generously to support skin recovery.
• Avoid alcohol, saunas, steam rooms, hot baths, and intense exercise for 3-7 days after treatment.
• Stay out of direct sunlight and apply SPF 50+ sunscreen diligently.
• Do not apply makeup for at least 6-12 hours after the procedure.

Most patients can return to normal activities immediately after the treatment, making PDRN an excellent "lunchbreak procedure" — ideal for international visitors who do not want to sacrifice vacation time.

Best Clinics for PDRN in Seoul

Here are five well-regarded Seoul clinics that offer PDRN injections and cater to international patients with English-language support:

1. Oracle Clinic (Gangnam)

• Location: Gangnam-gu, Seoul (near Gangnam Station, Exit 10)
• Specialty: Comprehensive aesthetic treatments including PDRN, Rejuran, Botox, fillers, and laser treatments
• English Support: Full English-speaking staff and consultation available
• Why Choose: One of Korea's largest dermatology chains with extensive experience treating international patients

2. Hus-hu Dermatology (Gangnam)

• Location: Gangnam-gu, Seoul
• Specialty: Skin boosters, acne treatment, pigmentation correction, anti-aging injections
• English Support: English, Japanese, and Mandarin available
• Why Choose: Established in 2008, Hus-hu is one of the most recognized foreigner-friendly clinics in Seoul with multilingual staff and a strong reputation for personalized care

3. CnP Skin (Cha & Park Dermatology)

• Location: Multiple branches across Seoul (Gangnam, Myeongdong, and more)
• Specialty: PDRN "healing injections," laser treatments, skin analysis, and comprehensive skincare programs
• English Support: Available at major branches
• Why Choose: CnP (Cha & Park) specifically markets their PDRN protocol as a "healing injection" that enhances the skin's natural regenerative ability, combining PDRN with their proprietary treatment approach

4. ToxNFill Clinic (Multiple Locations)

• Location: Multiple branches in Seoul including Gangnam and central Seoul
• Specialty: PDRN salmon injections, Botox, fillers, skin boosters
• English Support: English online consultation available; upload photos for remote diagnosis and treatment planning
• Why Choose: Offers convenient online pre-consultation so international patients can plan their treatment before arriving in Korea

5. Abijou Clinic (Gangnam)

• Location: Gangnam-gu, Seoul
• Specialty: Petit procedures, skin management, PDRN, fillers, laser treatments
• English Support: Full English website (abijouclinic.com/eng) and English-speaking staff
• Why Choose: Boutique-style clinic with a dedicated English-language platform, making it easy for international visitors to book appointments and understand treatment options

Tip: When booking as an international patient, ask about package deals for multiple PDRN sessions. Many clinics offer discounted rates when you book a full treatment course, and some include post-treatment skincare products in the package.

Frequently Asked Questions

Q: Is PDRN safe for all skin types? A: Yes, PDRN is biocompatible with human tissue and suitable for all skin types and tones. The main contraindication is a known allergy to salmon or seafood. Always disclose allergies during your consultation.

Q: How soon will I see results from PDRN injections? A: Most patients notice an improvement in skin hydration and texture after the first session. However, the full benefits — including collagen stimulation, reduced fine lines, and improved elasticity — typically become visible after 3-5 sessions over the course of several weeks.

Q: Does PDRN hurt? A: A topical numbing cream is applied before the procedure, so most patients describe the sensation as mild pinching or slight discomfort rather than pain. The fine needles used minimize discomfort significantly.

Q: Can I combine PDRN with other treatments? A: Absolutely. Korean dermatologists frequently combine PDRN with Rejuran (PN), Botox, fillers, or laser treatments for comprehensive skin rejuvenation. Your doctor will recommend the best combination based on your skin analysis.

Q: Is PDRN covered by insurance in Korea? A: No. PDRN injections for aesthetic purposes are classified as non-covered (non-insurance) procedures in Korea. All costs are out-of-pocket, which is why prices vary between clinics.

Q: How long do PDRN results last? A: Results from a full course of PDRN treatments (3-5 sessions) typically last 3-6 months. Maintenance sessions every 2-3 months are recommended to sustain the rejuvenation effects. Combining in-clinic treatments with PDRN-infused skincare products at home can help extend the results.

Final Thoughts

PDRN salmon DNA injections represent one of the best value propositions in Korean aesthetic medicine. With prices starting as low as ₩80,000 ($60) per session in Seoul — a fraction of what you would pay in Western countries — and a strong safety profile backed by decades of medical research, it is easy to see why this treatment has become a must-try for international visitors to Korea.

Whether you are looking to address fine lines, acne scars, uneven texture, or simply want to achieve that coveted Korean glass skin glow, PDRN offers a scientifically proven path to healthier, more radiant skin. Pair it with a Rejuran session for deep dermal renewal, and you have a comprehensive Korean skin rejuvenation protocol that delivers real results.

Ready to book your PDRN treatment in Seoul? Contact any of the clinics listed above for an English-language consultation, and start your Korean skin rejuvenation journey today.

⚠️ Medical Disclaimer: This article provides general information about PDRN (Polydeoxyribonucleotide) injections and is intended for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Individual results may vary. Always consult with a qualified dermatologist or healthcare professional before undergoing any cosmetic or medical procedure. The clinics mentioned in this article are listed for informational purposes and do not constitute endorsements.

Last Updated: February 2026 Reading Time: 8 minutes